Article

Improving the preclinical and clinical success rates of LMW drugs depends on radical revisions to the status quo scientific foundations of medicinal chemistry: a case study on COVID M <sup>pro</sup> inhibition

2022-11-02

Abstract excerpt

The poor preclinical and clinical success rates of low molecular weight (LMW) compounds can be partially attributed to the inherent trial-and-error nature of pharmaceutical research, which is limited largely to retrospective data-driven, rather than prospective prediction-driven human relevant workflows stemming from: 1) inadequate scientific understanding of structure-activity, structure-property, and structure...

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Literature Corpus work: 22182ae9-2ec9-50c3-858c-d7613aac67a0
DOI: 10.1101/2022.10.31.514572

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Improving the preclinical and clinical success rates of LMW drugs depends on radical revisions to the status quo scientific foundations of medicinal chemistry: a case study on COVID M <sup>pro</sup> inhibitionDOI 10.1101/2022.10.31.514572Read

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