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Article

Altered residence time as a cause of drug resistance.

Current opinion in structural biology - 1 Apr 2026

Farrell Brian M, Seeliger Markus A

Abstract excerpt

Drug-target residence time is a crucial determinant of pharmacological efficacy, complementing traditional equilibrium affinity measures. Variations in residence time influence drug selectivity, therapeutic windows, and resistance development, yet its molecular underpinnings remain incompletely understood. Here we review factors governing residence time, including kinetic parameters and structural influences, and...

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PMID: 41687504
DOI: 10.1016/j.sbi.2026.103219

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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