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Article

Elements and modulation of functional dynamics.

Journal of medicinal chemistry - 9 Oct 2014

Gibbs Alan C

Abstract excerpt

The existing structure-function paradigm of drug discovery has been evolving toward the essential incorporation of dynamics data. This new functional dynamics paradigm emphasizes conformational entropy as a driving force of protein function and intermolecular recognition. Conformational dynamics (a proxy of conformational entropy) impacts the degree of protein (dis)order and the constitution of the conformational...

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Identifiers

PMID: 24913411
DOI: 10.1021/jm500325k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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