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Article

SETDB1 Inhibits p53-Mediated Apoptosis and Is Required for Formation of Pancreatic Ductal Adenocarcinomas in Mice

28 Apr 2020

Abstract excerpt

Background & Aims SETDB1, a histone methyltransferase that trimethylates histone H3 on lysine 9, promotes development of several tumor types. We investigated whether SETDB1 contributes to development of pancreatic ductal adenocarcinoma (PDAC). Methods We performed studies with Ptf1a Cre ; Kras G12D ; Setdb1 f/f , Ptf1a Cre ; Kras G12D ; Trp53 f/+ ; Setdb1 f/f , and Ptf1a Cre ; Kras G12D ; Trp53 f/f ; Setdb1 f/f...

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Share to Cancer-related Molecular Pathways
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PMID: 32360551
DOI: 10.1053/j.gastro.2020.04.047

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