Article
Spink1 promotes the survival of Kras-mutant pancreatic acinar cells.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 May 2026
Hayashi Hidehiro, Hamada Shin, Matsumoto Ryotaro, Takikawa Tetsuya, Xu Yan, Jie Ren, Nakasuji Hitomi, Abe Toshiaki, Kikuta Kazuhiro, Motohashi Hozumi, Ohmuraya Masaki, Masamune Atsushi
Abstract excerpt
BACKGROUND: Pancreatic cancer remains one of the most intractable malignancies due to its strong therapeutic resistance and the difficulty of early detection. Previous studies have suggested that pancreatic inflammation can promote carcinogenesis. In contrast, the regulatory mechanisms controlling trypsin activity are closely associated with susceptibility to pancreatitis. Genetic variants that lead to sustained...
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