Article

An essential post-developmental role for Lis1 in mice

2017-11-01

Abstract excerpt

<h4>ABSTRACT</h4> LIS1 mutations cause lissencephaly (LIS), a severe developmental brain malformation. Much less is known about its role in the mature nervous system. LIS1 regulates the microtubule motor cytoplasmic dynein 1 (dynein), and as LIS1 and dynein are both expressed in the adult nervous system, Lis1 could potentially regulate dynein-dependent processes such as axonal transport. We therefore knocked out...

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Literature Corpus work: 220cbbda-8396-532b-a0f3-bd41856e3333
DOI: 10.1101/212340

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