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Article

Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly.

Nature medicine - 1 Oct 2009

Yamada Masami, Yoshida Yuko, Mori Daisuke, Takitoh Takako, Kengaku Mineko, Umeshima Hiroki, Takao Keizo, Miyakawa Tsuyoshi, Sato Makoto, Sorimachi Hiroyuki, Wynshaw-Boris Anthony, Hirotsune Shinji

Abstract excerpt

Lissencephaly is a devastating neurological disorder caused by defective neuronal migration. LIS1 (official symbol PAFAH1B1, for platelet-activating factor acetylhydrolase, isoform 1b, subunit 1) was identified as the gene mutated in individuals with lissencephaly, and it was found to regulate cy...

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Identifiers

PMID: 19734909
DOI: 10.1038/nm.2023
PMCID: PMC2759411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19734909-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly.PMID 19734909Read ↗

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Lissencephaly 1 linking to multiple diseases: mental retardation, neurodegeneration, schizophrenia, male sterility, and more.Semantic proximity Read ↗

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