Article

Determinants for forming a supramolecular myelin-like proteolipid lattice

2020-02-07

Abstract excerpt

Myelin protein P2 is a peripheral membrane protein of the fatty acid binding protein family. It functions in the formation and maintenance of the peripheral nerve myelin sheath, and several P2 mutations causing human Charot-Marie-Tooth neuropathy have been reported. Here, electron cryomicroscopy of myelin-like proteolipid multilayers revealed a three-dimensionally ordered lattice of P2 molecules between stacked li...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 220415d3-b54f-506f-804a-d3230aefcfa3
DOI: 10.1101/2020.02.06.937177

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Determinants for forming a supramolecular myelin-like proteolipid latticeDOI 10.1101/2020.02.06.937177Read

Human myelin protein P2: From crystallography to time-lapse membrane imaging and neuropathy-associated variantsSemantic proximity Read

Effects of Lid Domain Structural Changes on the Interactions between Peripheral Myelin Protein 2 and a Lipid Bilayer.Semantic proximity Read

Human myelin protein P2: from crystallography to time-lapse membrane imaging and neuropathy-associated variants.Semantic proximity Read

Molecular structure and function of myelin protein P0 in membrane stackingSemantic proximity Read

Structure and dynamics of a human myelin protein P2 portal region mutant indicate opening of the β barrel in fatty acid binding proteins.Semantic proximity Read

Peripheral myelin protein 22 alters membrane architecture.Semantic proximity Read

Peripheral myelin protein 22 preferentially partitions into ordered phase membrane domains.Semantic proximity Read

Flexible Players within the Sheaths: The Intrinsically Disordered Proteins of Myelin in Health and DiseaseSemantic proximity Read

A Nanoscale Model System for the Human Myelin SheathSemantic proximity Read

Peripheral Myelin Protein 22 Preferentially Partitions into Ordered Phase Membrane DomainsSemantic proximity Read

Conformational changes associated with L16P and T118M mutations in the membrane-embedded PMP22 protein, consequential in CMT-1A.Semantic proximity Read

Structural context of homomeric interactions in the lg domain of the MPZ (P0) myelin adhesion protein and relation to Charcot-Marie-Tooth disease phenotype variantsSemantic proximity Read