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Article

Peripheral myelin protein 22 alters membrane architecture.

Science advances - 1 Jul 2017

Mittendorf Kathleen F, Marinko Justin T, Hampton Cheri M, Ke Zunlong, Hadziselimovic Arina, Schlebach Jonathan P, Law Cheryl L, Li Jun, Wright Elizabeth R, Sanders Charles R, Ohi Melanie D

Abstract excerpt

Peripheral myelin protein 22 (PMP22) is highly expressed in myelinating Schwann cells of the peripheral nervous system. PMP22 genetic alterations cause the most common forms of Charcot-Marie-Tooth disease (CMTD), which is characterized by severe dysmyelination in the peripheral nerves. However, the functions of PMP22 in Schwann cell membranes remain unclear. We demonstrate that reconstitution of purified PMP22...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28695207
DOI: 10.1126/sciadv.1700220
PMCID: PMC5498104

Genes

PMP22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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