Article
Peripheral myelin protein 22 preferentially partitions into ordered phase membrane domains.
Proceedings of the National Academy of Sciences of the United States of America - 23 Jun 2020
Marinko Justin T, Kenworthy Anne K, Sanders Charles R
Abstract excerpt
The ordered environment of cholesterol-rich membrane nanodomains is thought to exclude many transmembrane (TM) proteins. Nevertheless, some multispan helical transmembrane proteins have been proposed to partition into these environments. Here, giant plasma membrane vesicles (GPMVs) were employed to quantitatively show that the helical tetraspan peripheral myelin protein 22 (PMP22) exhibits a pronounced preference...
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