Article

Human myelin protein P2: From crystallography to time-lapse membrane imaging and neuropathy-associated variants

2021-04-15

Abstract excerpt

Peripheral myelin protein 2 (P2) is a fatty acid-binding protein expressed in vertebrate peripheral nervous system myelin, as well as in human astrocytes. Suggested functions of P2 include membrane stacking and lipid transport. Mutations in the PMP2 gene, encoding P2, are associated with Charcot-Marie-Tooth disease (CMT). Recent studies have revealed three novel PMP2 mutations in CMT patient families. To shed li...

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Literature Corpus work: 96bee488-aa66-5bf8-822b-bb0d4ddc4c74
DOI: 10.1101/2021.04.15.439958

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