Article

Structural context of homomeric interactions in the lg domain of the MPZ (P0) myelin adhesion protein and relation to Charcot-Marie-Tooth disease phenotype variants

2023-03-19

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in Myelin Protein Zero (MPZ) account for 5% of Charcot-Marie-Tooth cases and can cause demyelinating or axonal phenotypes, reflecting the diverse roles of MPZ in Schwann cells. MPZ holds the apposing membranes of the myelin sheath together, with the adhesion role fulfilled by the extracellular lmmunoglobulin-like domain (lg MPZ ), which can oligomerize. Current knowledge for how the l...

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Literature Corpus work: 345168ce-2761-515a-b6a1-5acdb66f5afd
DOI: 10.1101/2023.03.18.533291

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