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Article

Structure and dynamics of a human myelin protein P2 portal region mutant indicate opening of the β barrel in fatty acid binding proteins.

BMC structural biology - 25 Jun 2018

Laulumaa Saara, Nieminen Tuomo, Raasakka Arne, Krokengen Oda C, Safaryan Anushik, Hallin Erik I, Brysbaert Guillaume, Lensink Marc F, Ruskamo Salla, Vattulainen Ilpo, Kursula Petri

Abstract excerpt

BACKGROUND: Myelin is a multilayered proteolipid sheath wrapped around selected axons in the nervous system. Its constituent proteins play major roles in forming of the highly regular membrane structure. P2 is a myelin-specific protein of the fatty acid binding protein (FABP) superfamily, which is able to stack lipid bilayers together, and it is a target for mutations in the human inherited neuropathy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29940944
DOI: 10.1186/s12900-018-0087-2
PMCID: PMC6020228

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