Back to search

Article

The <i>ift140</i> -Deficient Zebrafish: A Model for Renal Cystogenesis and an F0-Based Screen to Identify Genetic Modifiers of Kidney Cysts

2025-01-03

Abstract excerpt

Genetic modifiers are believed to play an important role in the onset and severity of polycystic kidney disease (PKD), but identifying these modifiers has been challenging due to the lack of effective methodologies. In this study, we investigated zebrafish mutants of IFT140 , a newly identified ADPKD gene, and observed phenotypes similar to those seen in mammalian models, including kidney cysts and bone defects....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
21e62c98-2a48-5b7f-80bf-9dbac885e386
DOI
10.1101/2025.01.02.631132
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The <i>ift140</i> -Deficient Zebrafish: A Model for Renal Cystogenesis and an F0-Based Screen to Identify Genetic Modifiers of Kidney CystsDOI 10.1101/2025.01.02.631132
<i>mtor</i> Haploinsufficiency Ameliorates Renal Cyst Formation in Adult Zebrafish <i>tmem67</i> MutantsSemantic proximity
mtor Haploinsufficiency Ameliorates Renal Cysts and Cilia Abnormality in Adult Zebrafish tmem67 MutantsSemantic proximity
Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms.Semantic proximity
Monoallelic IFT140 pathogenic variants are an important cause of the autosomal dominant polycystic kidney-spectrum phenotype.Semantic proximity
Inactivation of <i>Nphp2</i> in renal epithelial cells drives infantile nephronophthisis like phenotypes in mouseSemantic proximity
Exome Reanalysis Identifies Novel Candidate Genes Associated with Congenital Anomalies of the Kidney and Urinary Tract in ChinaSemantic proximity
Implication of<i>FOXD2</i>dysfunction in syndromic congenital anomalies of the kidney and urinary tract (CAKUT)Semantic proximity
Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development.Semantic proximity
A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney.Semantic proximity
Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants.Semantic proximity
Patient-derived kidney organoids recapitulate ADPKD and facilitate the identification of Rho pathway inhibitors as candidate therapeutics.Semantic proximity
Human pluripotent stem cell-derived kidney organoids reveal tubular epithelial pathobiology of heterozygous <i>HNF1B</i> -associated dysplastic kidney malformationsSemantic proximity
Select a neighboring publication to make it the new centre.