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Article

A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney.

Development (Cambridge, England) - 1 Aug 2004

Sun Zhaoxia, Amsterdam Adam, Pazour Gregory J, Cole Douglas G, Miller Mark S, Hopkins Nancy

Abstract excerpt

Polycystic kidney disease (PKD) is a common human genetic illness. It is characterized by the formation of multiple kidney cysts that are thought to result from over-proliferation of epithelial cells. Zebrafish larvae can also develop kidney cysts. In an insertional mutagenesis screen in zebrafish, we identified 12 genes that can cause cysts in the glomerular-tubular region when mutated and we cloned 10 of these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15269167
DOI: 10.1242/dev.01240

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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