Article

Uncovering porphyrin accumulation in the tumor microenvironment

2024-04-14

Abstract excerpt

Heme, an iron-containing tetrapyrrole, is essential in almost all organisms. Heme biosynthesis needs to be exquisitely regulated particularly given the potential cytotoxicity of protoporphyrin IX, the intermediate preceding heme formation. Here, we report on the porphyrin intermediate accumulation within the tumor microenvironment (TME), which we propose to result from dysregulation of heme biosynthesis concomitan...

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Literature Corpus work: c781649f-76fe-5665-ae4f-b0fa29a36916
DOI: 10.1101/2024.04.11.589133

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