Article

Glycan Clock Forecasts Human Influenza A Virus Hemagglutinin Evolution

2017-07-13

Abstract excerpt

<h4>ABSTRACT</h4> Adaptive immunity to influenza A virus is limited by frequent mutations in the immunodominant head of hemagglutinin (HA). Over the last century, the upward trend in HA-head glycosylation indicates glycan addition can increase fitness, but its role in viral evolution remains unclear. Here, we report glycan evolution follows a clock-like rhythm, pacing the timeline, trajectory, and replacement of...

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Literature Corpus work: 218ea64d-ef2c-55a3-b5c4-fb31e96611be
DOI: 10.1101/163345

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