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Article

New Multidrug Efflux Inhibitors for Gram-Negative Bacteria

13 Jul 2020

Abstract excerpt

Multidrug-resistant Gram-negative bacteria pose a serious threat to human and animal health. Molecules that inhibit multidrug efflux offer an alternative approach to resolving the challenges caused by antibiotic resistance, by potentiating the activity of old, licensed, and new antibiotics. We have developed, validated, and implemented a high-throughput screen and used it to identify efflux inhibitors from two...

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Share to Antibiotic Resistance in Bacteria
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32665275
DOI: 10.1128/mbio.01340-20

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