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Article

New understanding of multidrug efflux and permeation in antibiotic resistance, persistence, and heteroresistance

7 Nov 2022

Abstract excerpt

Antibiotics effective against Gram-negative ESKAPE pathogens are a critical area of unmet need. Infections caused by these pathogens are not only difficult to treat but finding new therapies to overcome Gram-negative resistance is also a challenge. There are not enough antibiotics in development that target the most dangerous pathogens and there are not enough novel drugs in the pipeline. The major obstacle in...

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PMID: 36344198
DOI: 10.1111/nyas.14921

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