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Update on the Discovery of Efflux Pump Inhibitors against Critical Priority Gram-Negative Bacteria

15 Jan 2023

Abstract excerpt

Antimicrobial resistance (AMR) has become a major problem in public health leading to an estimated 4.95 million deaths in 2019. The selective pressure caused by the massive and repeated use of antibiotics has led to bacterial strains that are partially or even entirely resistant to known antibiotics. AMR is caused by several mechanisms, among which the (over)expression of multidrug efflux pumps plays a central...

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PMID: 36671381
DOI: 10.3390/antibiotics12010180

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