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Article

Rχ-01, a New Family of Oxazolidinones That Overcome Ribosome-Based Linezolid Resistance

28 Jul 2008

Abstract excerpt

New and improved antibiotics are urgently needed to combat the ever-increasing number of multidrug-resistant bacteria. In this study, we characterized several members of a new oxazolidinone family, R chi-01. This antibiotic family is distinguished by having in vitro and in vivo activity against hospital-acquired, as well as community-acquired, pathogens. We compared the 50S ribosome binding affinity of this...

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PMID: 18663023
DOI: 10.1128/aac.01193-07

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