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Structure–Uptake Relationship Studies of Oxazolidinones in Gram-Negative ESKAPE Pathogens

18 Oct 2022

Abstract excerpt

The clinical success of linezolid for treating Gram-positive infections paired with the high conservation of bacterial ribosomes predicts that if oxazolidinones were engineered to accumulate in Gram-negative bacteria, then this pharmacological class would find broad utility in eradicating infections. Here, we report an investigative study of a strategically designed library of oxazolidinones to determine the...

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PMID: 36257060
DOI: 10.1021/acs.jmedchem.2c01349

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