Article

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2

2021-01-14

Abstract excerpt

SARS-CoV-2 entry into host cells is orchestrated by the spike (S) glycoprotein that contains an immunodominant receptor-binding domain (RBD) targeted by the largest fraction of neutralizing antibodies (Abs) in COVID-19 patient plasma. Little is known about neutralizing Abs binding to epitopes outside the RBD and their contribution to protection. Here, we describe 41 human monoclonal Abs (mAbs) derived from memory...

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Literature Corpus work: c26d1b09-b1bb-5fab-a2d6-f59c96b524f0
DOI: 10.1101/2021.01.14.426475

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