Article

MHC-II constrains the natural neutralizing antibody response to the SARS-CoV-2 spike RBM in humans

2020-12-28

Abstract excerpt

SARS-CoV-2 antibodies develop within two weeks of infection, but wane relatively rapidly post-infection, raising concerns about whether antibody responses will provide protection upon re-exposure. Here we revisit T-B cooperation as a prerequisite for effective and durable neutralizing antibody responses centered on a mutationally constrained RBM B cell epitope. T-B cooperation requires co-processing of B and T cel...

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Identifiers and source

Literature Corpus work: 6ba92b6c-26fa-5521-bb73-2164c7f0262b
DOI: 10.1101/2020.12.26.424449

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