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Article

Hyaluronan catabolism supports the peritoneal disseminated metastasis of cancer through the glucuronic acid pathway

2025-11-19

Abstract excerpt

<title>Abstract</title> <p>When disseminated into the peritoneal cavity at the very early stage, cancer cells must adapt to the glucose- and oxygen-limited environment in peritoneal fluid. To investigate the molecular mechanisms enabling this adaptation, we conducted a genome-wide CRISPR/Cas9 knockout screening in an orthotopic ovarian cancer (OC) model. We identified a series of genes involved in hyaluronic acid...

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Literature Corpus work
216b82cf-ca73-5a79-9962-03ebb61bfc85
DOI
10.21203/rs.3.rs-7691213/v1
Open publication

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Hyaluronan catabolism supports the peritoneal disseminated metastasis of cancer through the glucuronic acid pathwayDOI 10.21203/rs.3.rs-7691213/v1
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