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The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage

2025-01-14

Abstract excerpt

The excessive production of extracellular matrix (ECM) and the metabolic adaptations in pancreatic ductal adenocarcinoma (PDAC) contribute individually to enhanced chemoresistance, dramatic tumor progression and dismal patient survival. However, ECM-driven metabolic alterations that promote chemoresistance in PDAC are so far unexplored. Here, we use in-vitro -generated ECM bio-scaffolds that recapitulate cell-ECM...

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Literature Corpus work
20421b52-5bf9-5c14-bb1e-13edd46f2806
DOI
10.1101/2025.01.10.631286
Open publication

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The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damageDOI 10.1101/2025.01.10.631286
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