Article

Convergent approaches to delineate the metabolic regulation of tumor invasion by hyaluronic acid biosynthesis

2022-06-09

Abstract excerpt

Metastasis is the leading cause of breast cancer-related deaths and often driven by invasion and cancer-stem like cells (CSCs). Both the CSC phenotype and invasion have been associated with increased hyaluronic acid (HA) production. How these independent observations are connected, and which role metabolism plays in this process remains unclear due in part to the lack of convergent approaches that integrate engine...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6600ea33-1070-5bce-aad0-f4499bf16764
DOI: 10.1101/2022.06.08.495338

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Convergent approaches to delineate the metabolic regulation of tumor invasion by hyaluronic acid biosynthesisDOI 10.1101/2022.06.08.495338Read

Cancer Stem Cell-Associated Pathways in the Metabolic Reprogramming of Breast CancerSemantic proximity Read

The Use of Patient-Derived Organoids in the Study of Molecular Metabolic Adaptation in Breast CancerSemantic proximity Read

Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transitionSemantic proximity Read

Metabolic characterization of aggressive breast cancer cells exhibiting invasive phenotype: impact of non-cytotoxic doses of 2-DG on diminishing invasivenessSemantic proximity Read

Systematic alteration of in vitro metabolic environments reveals empirical growth relationships in cancer cell phenotypes.Semantic proximity Read

Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancerSemantic proximity Read

Single-cell RNA sequencing has unveiled the contribution of ADSCs in reprogramming metabolism in triple-negative breast cancerSemantic proximity Read

Biglycan Promotes Cancer Stem Cell Properties, NFκB Signaling and Metastatic Potential in Breast Cancer CellsSemantic proximity Read

Identifying personalized metabolic signatures in breast cancerSemantic proximity Read

Characterization of metabolic phenotypes in breast cancer through the integration of genome-scale metabolic models and machine learningSemantic proximity Read

Metabolic characterization of aggressive breast cancer cells exhibiting invasive phenotype: Impact of non-cytotoxic doses of 2-DG on diminishing invasivenessSemantic proximity Read

Hyaluronan catabolism supports the peritoneal disseminated metastasis of cancer through the glucuronic acid pathwaySemantic proximity Read