Back to search

Article

RORα inhibits proliferation and chemoresistance through AKR1A1-induced glucose and lipid reprogramming in gastric cancer

2024-09-16

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Abnormal glycolysis and lipid synthesis play important roles in the occurrence and development of gastric cancer (GC).Moreover, dysregulation of circadian genes was associated with metabolic reprogramming in the tumor microenvironment. This study aimed to decipher the role of retinoic acid-related orphan receptor alpha (RORα) in glucose and lipid reprogramming of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f9f2fcbc-56d6-5580-8e30-c9fe1099a817
DOI
10.21203/rs.3.rs-4864679/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
RORα inhibits proliferation and chemoresistance through AKR1A1-induced glucose and lipid reprogramming in gastric cancerDOI 10.21203/rs.3.rs-4864679/v1
RORα inhibits gastric cancer proliferation through attenuating G6PD and PFKFB3 induced glycolytic activitySemantic proximity
High SLC2A1 expression associated with suppressing CD8 T cells and B cells promoted cancer survival in gastric cancer.Semantic proximity
ESRRA promotes gastric cancer development by regulating the CDC25C/CDK1/CyclinB1 pathway via DSN1Semantic proximity
Unraveling the physiological roles of retinoic acid receptor-related orphan receptor αSemantic proximity
Rev-erbα inhibits proliferation by reducing glycolytic flux and pentose phosphate pathway in human gastric cancer cellsSemantic proximity
Knockdown of PGM1 Synergistically Enhances Anticancer Effects of Orlistat in Gastric Cancer Under Glucose DeprivationSemantic proximity
Glycolysis-mTORC1 crosstalk drives rapid proliferation in patient-derived endometrial cancer spheroids with ALDH activitySemantic proximity
The FTO-regulated circNFATC3/miR-23b-3p axis promotes RAI14-mediated gastric cancer progression via lipid metabolic reprogrammingSemantic proximity
RORγ is a context-specific master regulator of cholesterol biosynthesis and an emerging therapeutic target in cancer and autoimmune diseasesSemantic proximity
RORβ suppresses the stemness of gastric cancer cells by downregulating the activity of the Wnt signaling pathwaySemantic proximity
Identification and validation of a novel LncRNA TRG-AS1 that inhibits colorectal cancer proliferation and glycolysisSemantic proximity
Shared Genetic Architecture between Gastric Cancer and Medication-Use Phenotypes in East Asians Reveals Lipid-Metabolic Pathways and Candidate Cellular ContextsSemantic proximity
Select a neighboring publication to make it the new centre.