Article
Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production.
Nature communications - 1 Jan 2013
Dimitrov Mitko, Alattia Jean-René, Lemmin Thomas, Lehal Rajwinder, Fligier Andrzej, Houacine Jemila, Hussain Ishrut, Radtke Freddy, Dal Peraro Matteo, Beher Dirk, Fraering Patrick C
Abstract excerpt
Pathological amino-acid substitutions in the amyloid precursor protein (APP) and chemical γ-secretase modulators affect the processing of APP by the γ-secretase complex and the production of the amyloid-beta peptide Aβ42, the accumulation of which is considered causative of Alzheimer's disease. Here we demonstrate that mutations in the transmembrane domain of APP causing aggressive early-onset familial...
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