Article

Estimating Intraclonal Heterogeneity and Subpopulation Changes from Perturbational Bulk Gene Expression Profiles in LINCS L1000 CMap by Premnas

2021-08-10

Abstract excerpt

<h4>Background</h4> The connectivity among signatures upon perturbations curated in the CMap library provides a valuable resource for understanding therapeutic pathways and biological processes associated with the drugs and diseases. <h4>Motivation</h4> However, due to the nature of bulk-level expression profiling by the L1000 assay, intraclonal heterogeneity and subpopulation compositional change that could con...

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Literature Corpus work: 210b9a5a-5deb-5ae4-830b-1ffd78663ac5
DOI: 10.1101/2021.08.10.455781

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