Article

Reliable and accurate gene expression quantification with subpopulation structure-aware constraints for single-cell RNA sequencing

2022-11-09

Abstract excerpt

<h4>Background</h4> Single-cell RNA sequencing (scRNA-seq) analysis analyzes the type and state of individual cells by estimating the gene expression of each cell and enables researchers to study the biological phenomena that cannot be observed in bulk RNA sequencing. <h4>Motivation</h4> However, the current scRNA-seq quantification tools estimate the gene expression profile of each cell independently, ignoring...

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Literature Corpus work: 28c04753-929a-58c2-a751-b7d2e451ff8d
DOI: 10.1101/2022.11.08.515740

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