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Mutations in genes <i>lpxL1, bamA</i> and <i>pmrB</i> impair the susceptibility of cystic fibrosis strains of <i>Pseudomonas aeruginosa</i> to murepavadin

2023-10-13

Abstract excerpt

Murepavadin is a peptidomimetic exhibiting specific inhibitory activity against Pseudomonas species. In the present study, its in vitro activity was assessed on 230 cystic fibrosis (CF) strains of P. aeruginosa isolated from twelve French hospitals, in comparison with twelve other antipseudomonal antibiotics. Although murepavadin is still in pre-clinical stage of development, 9.1% ( n =21) of the strains displ...

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Literature Corpus work
21098af2-d8e6-507a-a109-f5ba93235801
DOI
10.1101/2023.10.09.561565
Open publication

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Mutations in genes <i>lpxL1, bamA</i> and <i>pmrB</i> impair the susceptibility of cystic fibrosis strains of <i>Pseudomonas aeruginosa</i> to murepavadinDOI 10.1101/2023.10.09.561565
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