Article

Distinctive Lacritin Cleavage-Potentiated Bactericidal Alteration of the <i>P. aeruginosa</i> Transcriptome

2026-03-18

Abstract excerpt

Lacritin is a tear, saliva, plasma and cerebrospinal fluid glycoprotein with broad polypharmacology. Selective deficiency of its bioactive monomeric form appears to be deleterious for ocular surface health for which replacement therapy is beneficial. Its cleavage-potentiated C-terminus represented by the N-104 proteoform in tears is bactericidal and synergizes with the tear thrombin peptide GKY20. In the pathogeni...

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Literature Corpus work: fd1990e8-413e-5bf7-a24d-566fdf16a1b5
DOI: 10.64898/2026.03.17.712309

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