Unravelling the mechanisms causing murepavadin resistance in Pseudomonas aeruginosa: lipopolysaccharide alterations and its consequences.

doi:10.3389/fcimb.2024.1446626

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Unravelling the mechanisms causing murepavadin resistance in Pseudomonas aeruginosa: lipopolysaccharide alterations and its consequences.

Frontiers in cellular and infection microbiology - 1 Jan 2024

Hernández-García Marta, Barbero-Herranz Raquel, Bastón-Paz Natalia, Díez-Aguilar María, López-Collazo Eduardo, Márquez-Garrido Francesc J, Hernández-Pérez José María, Baquero Fernando, Ekkelenkamp Miquel B, Fluit Ad C, Fuentes-Valverde Víctor, Moscoso Miriam, Bou Germán, Del Campo Rosa, Cantón Rafael, Avendaño-Ortiz José

Abstract excerpt

Introduction: Murepavadin is an antimicrobial peptide (AMP) in clinical development that selectively targets Pseudomonas aeruginosa LptD and whose resistance profile remains unknown. We aimed to explore genomic modifications and consequences underlying murepavadin and/or colistin susceptibility. Methods: To define genomic mechanisms underlying resistance, we performed two approaches: 1) a genome-wide association...

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PMID: 39711784
DOI: 10.3389/fcimb.2024.1446626
PMCID: PMC11659217

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