Article

<i>Pseudomonas aeruginosa</i> utilises host-derived polyamines to facilitate antimicrobial tolerance

2021-12-16

Abstract excerpt

Pseudomonas aeruginosa undergoes diversification during infection of the cystic fibrosis (CF) lung. Understanding these changes requires model systems that capture the complexity of the CF lung environment. We previously identified loss-of-function mutations in the two-component regulatory system sensor kinase gene pmrB , in P. aeruginosa from CF and from experimental infection of mice. Here, we demonstrate that...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 80a791e3-613f-55a2-83b6-3d599c6bfb16
DOI: 10.1101/2021.12.15.472801

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Pseudomonas aeruginosa</i> utilises host-derived polyamines to facilitate antimicrobial toleranceDOI 10.1101/2021.12.15.472801Read

Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa.Semantic proximity Read

Agmatine accumulation by <i>Pseudomonas aeruginosa</i> clinical isolates confers antibiotic tolerance and dampens host inflammationSemantic proximity Read

Pulmonary Pathogens Adapt to Immune Signaling Metabolites in the AirwaySemantic proximity Read

Spermidine and spermine are the natural substrates of the <i>Acinetobacter baumannii</i> AmvA multidrug efflux pumpSemantic proximity Read

Identification of genes important for response of <i>Pseudomonas aeruginosa</i> biofilms to ciprofloxacin exposureSemantic proximity Read

An effective response to respiratory inhibition by a <i>Pseudomonas aeruginosa</i> excreted quinoline promotes <i>Staphylococcus aureus</i> fitness and survival in co-cultureSemantic proximity Read

A combination of phenotypic responses and genetic adaptations enables <i>Staphylococcus aureus</i> to withstand inhibitory molecules secreted by <i>Pseudomonas aeruginosa</i>Semantic proximity Read

The LysR-type transcriptional regulator BsrA (PA2121) controls vital metabolic pathways in <i>Pseudomonas aeruginosa</i>Semantic proximity Read

Bacterial <i>cis</i>-2-unsaturated fatty acids found in the cystic fibrosis airway modulate virulence and persistence of <i>Pseudomonas aeruginosa</i>Semantic proximity Read

Molecular-genetic characterisation of arginine auxotrophy in the opportunistic human pathogen, Pseudomonas aeruginosaSemantic proximity Read

Carbapenem-resistance <i>oprD</i> mutations reshape <i>Pseudomonas aeruginosa</i> host-pathogen interactions during infectionSemantic proximity Read

Mutations in <i>pmrB</i> confer cross-resistance to the LptD inhibitor POL7080 and colistin in <i>Pseudomonas aeruginosa</i>Semantic proximity Read