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Macrolide therapy in <i>Pseudomonas aeruginosa</i> infections causes uL4 ribosomal protein mutations leading to high-level resistance

2022-02-28

Abstract excerpt

<h4>Summary</h4> <h4>Background</h4> Cystic fibrosis (CF) patients have reduced mucociliary clearance resulting in recurring and chronic bacterial lung infections. Pseudomonas aeruginosa is one of the most common pathogens to colonize the airways of CF patients and can persist in the lungs for decades. CF patients infected with P. aeruginosa are treated with macrolides to inhibit quorum sensing, mucoidity and...

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Literature Corpus work
7e3e3919-dc06-5593-b7a9-d1f6c39ba653
DOI
10.1101/2022.02.28.482231
Open publication

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Macrolide therapy in <i>Pseudomonas aeruginosa</i> infections causes uL4 ribosomal protein mutations leading to high-level resistanceDOI 10.1101/2022.02.28.482231
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