Article

Wingless signaling promotes lipid mobilization through signal-induced transcriptional repression

2023-01-26

Abstract excerpt

<h4>Summary</h4> Conserved Wnt/Wingless signaling plays pivotal roles in regulating normal development and energy metabolism in metazoans, and aberrant activation of Wnt signaling drives the pathogenesis of many diseases including cancer. However, the role of Wnt signaling in regulating cellular lipid homeostasis, particularly lipid mobilization, remains poorly understood. Here we show that canonical Wg signaling...

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Literature Corpus work: 2102ff42-667b-5325-8020-98ecd1639212
DOI: 10.1101/2023.01.25.525602

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