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Article

Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation

5 Jul 2017

Abstract excerpt

Browning of subcutaneous white fat (iWAT) involves several reprograming events, but the underlying mechanisms are incompletely understood. Here we show that the transcription factor Hlx is selectively expressed in brown adipose tissue (BAT) and iWAT, and is translationally upregulated by β3-adrenergic signaling-mediated suppression of the translational inhibitor 4E-BP1. Hlx interacts with and is co-activated by...

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PMID: 28701693
DOI: 10.1038/s41467-017-00098-2

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