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Nuclear HMGB1 protects from non-alcoholic fatty liver diseases through negative regulation of liver X receptor

2021-02-17

Abstract excerpt

Dysregulations of lipid metabolism in the liver may trigger steatosis progression leading to potentially severe clinical consequences such as non-alcoholic fatty liver diseases (NAFLD). Molecular mechanisms underlying liver lipogenesis are very complex and fine-tuned by chromatin dynamics and the activity of multiple key transcription factors. Here, we demonstrate that the nuclear factor HMGB1 acts as a strong rep...

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Identifiers and source

Literature Corpus work
10ce902f-1790-5061-9f36-778c308c50eb
DOI
10.1101/2021.02.17.431446
Open publication

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Nuclear HMGB1 protects from non-alcoholic fatty liver diseases through negative regulation of liver X receptorDOI 10.1101/2021.02.17.431446
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