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Article

PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control.

Cell death & disease - 1 Dec 2016

Zhuang Na, Li Lin, Chen She, Wang Tao

Abstract excerpt

Mitochondrial dysfunction has been linked to the pathogenesis of a large number of inherited diseases in humans, including Parkinson's disease, the second most common neurodegenerative disorder. The Parkinson's disease genes pink1 and parkin, which encode a mitochondrially targeted protein kinase, and an E3 ubiquitin ligase, respectively, participate in a key mitochondrial quality-control pathway that eliminates...

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Identifiers

PMID: 27906179
DOI: 10.1038/cddis.2016.396
PMCID: PMC5261015

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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