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Article

PINK1-Interacting Proteins: Proteomic Analysis of Overexpressed PINK1

1 Jan 2011

Abstract excerpt

Recent publications suggest that the Parkinson's disease- (PD-) related PINK1/Parkin pathway promotes elimination of dysfunctional mitochondria by autophagy. We used tandem affinity purification (TAP), SDS-PAGE, and mass spectrometry as a first step towards identification of possible substrates for PINK1. The cellular abundance of selected identified interactors was investigated by Western blotting. Furthermore,...

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Identifiers

PMID: 21437181
DOI: 10.4061/2011/153979

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