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Article

Molecular Investigation of Resistance to Second-Line Injectable Drugs in Multidrug-Resistant Clinical Isolates of Mycobacterium tuberculosis in France.

Antimicrobial agents and chemotherapy - 1 Feb 2017

Brossier Florence, Pham Anne, Bernard Christine, Aubry Alexandra, Jarlier Vincent, Veziris Nicolas, Sougakoff Wladimir

Abstract excerpt

The second-line injectable drugs (SLID, i.e., amikacin, kanamycin, capreomycin) are key drugs for the treatment of multidrug-resistant tuberculosis. Mutations in rrs region 1400, tlyA, and eis promoter are associated with resistance to SLID, to capreomycin, and to kanamycin, respectively. In this study, the sequencing data of SLID resistance-associated genes were compared to the results of phenotypic drug...

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Identifiers

PMID: 27895017
DOI: 10.1128/AAC.01299-16
PMCID: PMC5278698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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