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Efflux pump genes variants in MDR TB strains with discrepant phenotype-genotype correlations may further guide drug resistance interpretation

2023-04-13

Abstract excerpt

<h4>Introduction: </h4> Whole genome analysis of Mycobacterium tuberculosis (MTB) is an increasingly important method of identification of multi-drug resistance (MDR) in clinical isolates. It is based on the identification of single nucleotide variants (SNVs) in genes associated with resistance. However, there remain gaps in our understanding of phenotype – genotype correlation between strains. Efflux pumps contri...

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Literature Corpus work
ca5c368b-6d3d-54ff-949c-d22f3eaaf519
DOI
10.21203/rs.3.rs-2776346/v1
Open publication

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Efflux pump genes variants in MDR TB strains with discrepant phenotype-genotype correlations may further guide drug resistance interpretationDOI 10.21203/rs.3.rs-2776346/v1
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