Article

The role of dual specificity phosphatase 1 in pathological bone loss

2012-01-01

Abstract excerpt

Bone formation by osteoblasts (OBs) and bone resorption by osteoclasts (OCLs) is a tightly coupled and balanced process. In chronic inflammatory diseases such as rheumatoid arthritis (RA), this balance is disturbed and OCL activity exceeds that of OBs, leading to net bone loss or osteoporosis. Glucocorticoids (GC) are frequently used in treatment of inflammatory diseases. However, the long term use of GCs can lead...

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Literature Corpus work: 20d1f040-495e-57e4-9f55-4cacb5b110b0
DOI: 10.25560/10671

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