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Article

Dual specificity phosphatase 1 knockout mice show enhanced susceptibility to anaphylaxis but are sensitive to glucocorticoids.

Molecular endocrinology (Baltimore, Md.) - 1 Nov 2007

Maier Jana V, Brema Susanne, Tuckermann Jan, Herzer Ute, Klein Matthias, Stassen Michael, Moorthy Anbalagan, Cato Andrew C B

Abstract excerpt

Dual specificity phosphatase DUSP1 (otherwise known as mitogen-activated phosphatase 1 or MKP-1) dephosphorylates MAPKs, particularly p38, and negatively regulates innate immunity. Recent studies have shown that the DUSP1 gene is transcriptionally up-regulated by glucocorticoids (GCs) and that th...

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Source

Identifiers

PMID: 17636038
DOI: 10.1210/me.2007-0067

Genes

DUSP1
CCL2
DUSP2
DUSP4
DUSP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17636038-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Dual specificity phosphatase 1 knockout mice show enhanced susceptibility to anaphylaxis but are sensitive to glucocorticoids.PMID 17636038Read ↗

Regulation of dual specificity phosphatase 1 gene expression by glucocorticoidsSemantic proximity Read ↗

The role of dual specificity phosphatase 1 in pathological bone lossSemantic proximity Read ↗

Role and regulation of MKP-1 in airway inflammationSemantic proximity Read ↗

Glucocorticoid Resistance: Interference between the Glucocorticoid Receptor and the MAPK Signalling Pathways.Semantic proximity Read ↗

Essential role of MAPK phosphatase-1 in the negative control of innate immune responses.Semantic proximity Read ↗

Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice.Semantic proximity Read ↗

Characterization of a novel low-molecular-mass dual-specificity phosphatase-3 (LDP-3) that enhances activation of JNK and p38.Semantic proximity Read ↗

Deletion of Dual Specificity Phosphatase 1 Does Not Predispose Mice to Increased Spontaneous Osteoarthritis.Semantic proximity Read ↗

src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation.Semantic proximity Read ↗

p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211.Semantic proximity Read ↗

The dual-specificity phosphatase 2 (DUSP2) does not regulate obesity-associated inflammation or insulin resistance in mice.Semantic proximity Read ↗

Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development.Semantic proximity Read ↗

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