Article

Regulation of dual specificity phosphatase 1 gene expression by glucocorticoids

2010-01-01

Abstract excerpt

Dual specificity phosphatase 1 (DUSP1) limits the expression of pro-inflammatory gene products by dephosphorylating and inactivating mitogen-activated protein kinases (MAPKs), in particular p38 MAPK and cJun N-terminal kinase. In many mouse and human cell types, glucocorticoids (GCs) increase the expression of DUSP1. The resulting inhibition of intracellular signalling pathways is thought to contribute to the powe...

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Literature Corpus work: 06d5f344-3b93-5b18-a0f8-bec947255db1
DOI: 10.25560/5710

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