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Article

MKP-1 knockout does not prevent glucocorticoid-induced bone disease in mice.

Calcified tissue international - 1 Sept 2011

Conradie Maria M, Cato Andrew C B, Ferris William F, de Wet Heidi, Horsch Kay, Hough Stephen

Abstract excerpt

Glucocorticoid-induced osteoporosis (GCOP) is predominantly caused by inhibition of bone formation, resulting from a decrease in osteoblast numbers. Employing mouse (MBA-15.4) and human (MG-63) osteoblast cell lines, we previously found that the glucocorticoid (GC) dexamethasone (Dex) inhibits cellular proliferation as well as activation of the MAPK/ERK signaling pathway, essential for mitogenesis in these cells,...

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Source

Identifiers

PMID: 21698455
DOI: 10.1007/s00223-011-9509-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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