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Article

Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice.

Blood - 1 Apr 2004

Devlin Angela M, Arning Erland, Bottiglieri Teodoro, Faraci Frank M, Rozen Rima, Lentz Steven R

Abstract excerpt

Deficiency of methylenetetrahydrofolate reductase (MTHFR) predisposes to hyperhomocysteinemia and vascular disease. We tested the hypothesis that heterozygous disruption of the Mthfr gene sensitizes mice to diet-induced hyperhomocysteinemia and endothelial dysfunction. Mthfr(+/-) and Mthfr(+/+) mice were fed 1 of 4 diets: control, high methionine (HM), low folate (LF), or high methionine/low folate (HM/LF)....

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Source

Identifiers

PMID: 14630804
DOI: 10.1182/blood-2003-09-3078

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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