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Article

Supplementation with apple juice can compensate for folate deficiency in a mouse model deficient in methylene tetrahydrofolate reductase activity.

The journal of nutrition, health & aging - 1 Mar 2011

Chan A, Ortiz D, Rogers E, Shea T B

Abstract excerpt

Folate insufficiency promotes developmental as well as age-related disorders of the nervous system. The C677T variant of 5',10' methylene tetrahydrofolate reductase (MTHFR; which utilizes folate to regenerate methionine from homocysteine) displays reduced activity, and therefore promotes functional folate deficiency. Mice heterozygously lacking this gene (MTHFR+/- mice) represent a useful model for analysis of...

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Identifiers

PMID: 21369671
DOI: 10.1007/s12603-010-0295-3
PMCID: PMC12879596

Genes

MTHFR

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