Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methylenetetrahydrofolate Reductase Deficiency Deregulates Regional Brain Amyloid-β Protein Precursor Expression and Phosphorylation Levels.

Journal of Alzheimer's disease : JAD - 1 Jan 2018

Hoffman Alexander, Taleski Goce, Qian Helena, Wasek Brandi, Arning Erland, Bottiglieri Teodoro, Sontag Jean-Marie, Sontag Estelle

Abstract excerpt

Deregulation of the amyloid-β protein precursor (AβPP) plays a critical role in the neurodegenerative cascade of Alzheimer's disease (AD). Significantly, common functional polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene are a risk factor for the development of late-onset AD. Reduced MTHFR activity is associated with alterations in folate and homocysteine metabolism. Here, we first show...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid beta-Protein Precursor

Share to Folic Acid

Share to Glycogen Synthase Kinase 3 beta

Share to Homocysteine

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Phosphorylation

Source

Identifiers

PMID: 29865064
DOI: 10.3233/JAD-180032

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methylenetetrahydrofolate Reductase Deficiency Deregulates Regional Brain Amyloid-β Protein Precursor Expression and Phosphorylation Levels.PMID 29865064Read ↗

Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient miceSemantic proximity Read ↗

Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice.Semantic proximity Read ↗

Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy.Semantic proximity Read ↗

The <i>677C>T</i> variant in <i>methylenetetrahydrofolate reductase</i> causes morphological and functional cerebrovascular deficits in miceSemantic proximity Read ↗

Homocysteine Metabolites Inhibit Autophagy and Elevate Amyloid Beta by Impairing Phf8/H4K20me1-dependent Epigenetic Regulation of mTOR in Cystathionine β-Synthase-Deficient MiceSemantic proximity Read ↗

Epigenetic Factors in Late-Onset Alzheimer’s Disease: MTHFR and CTH Gene Polymorphisms, Metabolic Transsulfuration and Methylation Pathways, and B VitaminsSemantic proximity Read ↗

The effect of tau K677 lactylation on ferritinophagy and ferroptosis in Alzheimer's disease.Semantic proximity Read ↗

Induction of Alzheimer's-like changes in brain of mice expressing mutant APP fed excess methionine.Semantic proximity Read ↗

Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles.Semantic proximity Read ↗

Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition.Semantic proximity Read ↗

The C677T variant in MTHFR modulates associations between blood-based and cerebrospinal fluid biomarkers of neurodegeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.